Globally, railway is experiencing a major technology transformation (or paradigm shift), triggered by the enhanced utilisation of digital technology. This technological transformation affects not only the technical systems, i.e. railway infrastructure and rolling stock, but also regulations, organisations, processes,and individuals. Hence, hardware, software, but also liveware (i.e. humans) are affected. Today, the digitalisation of railway is characterised by digital services. There are also a range of challenges, e.g. data acquisition,transformation, modelling, processing, visualisation, safety, security, quality, and information assurance. To deal with these challenges, the railway industry needs to define strategies, which enable a smooth transformation of the existing configuration to a digitalised system. Digital railway requires a holistic change management approach based on system-of-systems thinking and a set of appropriate technologies and methodologies. The railway digitalisation strategy should be based on systematic risk management that address aspects of, e.g., information security, traffic safety and project risk. In addition, managing changes for a digitalised railway effectively and efficiently also requires a framework for aspects such as needs finding, requirement identification, and impact of changes for individual, teams and organisation. In this work a major case studywithin the ePilot, has been performed in context of the operation and maintenance processes of the Swedish railway. Therefore, this paper aims to propose a framework for implementing innovations and driving change in a digitalised railway.